Supplements / Conditional
Niacin (Vitamin B3)
Best for: Healthy aging
Niacin (Vitamin B3) is rated good evidence (tier B on our evidence scale). General-adequacy doses are 14–16 mg daily. Lipid-modifying doses (1–2 g) require clinician oversight, monitored liver enzymes, and immediate-release form only — sustained-release niacin at gram-scale doses has caused hepatotoxicity and is not recommended. Evening with food to mute flushing.
Sources last reviewed
When and how to take Niacin (Vitamin B3)
- Dose
- General-adequacy doses are 14–16 mg daily. Lipid-modifying doses (1–2 g) require clinician oversight, monitored liver enzymes, and immediate-release form only — sustained-release niacin at gram-scale doses has caused hepatotoxicity and is not recommended.
- Timing
- Evening with food to mute flushing.
- Review
- Reassess after 8 weeks with lipid panel and liver enzymes.
- Forms
- immediate-release niacin
What Niacin (Vitamin B3) is used for
- Real lipid signal at gram-scale doses; not appropriate without clinician oversight.
- Cardiovascular outcomes data is mixed despite the lipid effects (AIM-HIGH, HPS2-THRIVE).
- Sustained-release forms have a documented hepatotoxicity signal at lipid doses; this engine never auto-recommends gram-scale niacin without clinician routing.
Who should be careful with Niacin (Vitamin B3)
- Avoid if you have a history of liver issues.
- Check for interactions if you take prescription medication.
Safety checks for Niacin (Vitamin B3)
- Needs a clinician's OK: Polypharmacy (5+ prescriptions)
- Needs a clinician's OK: Any prescription medication
- Not suggested: Liver disease history
- Needs a clinician's OK: Glucose-lowering medications
What to look for when buying Niacin (Vitamin B3)
- Preferred third-party verification: USP Verified.
- Common contamination risks: Mislabeling / identity.
- Form: Immediate-release niacin has the lipid evidence but causes flushing. Sustained-release forms have hepatotoxicity risk.
Talk to a clinician first
This is a supplement we won’t link to a specific product without clinician context. Hepatotoxicity risk with sustained-release forms; flushing causes confusion with allergic reactions.Once we offer clinician partner pathways, this is where they’ll appear.
If you’re working with a doctor or qualified practitioner, they can advise on dose, brand, and monitoring.
Your experience
If you’ve tried Niacin (Vitamin B3), you can log how it went. This stays on your device — only you see it.
We frame these as personal experience, not medical claims. Self-reported subjective outcomes are influenced by placebo, regression to the mean, and parallel lifestyle changes. We’ll never present ratings as equivalent to RCT evidence.
Research sources for Niacin (Vitamin B3)
- Niacin for dyslipidemia: clinical review (reviewed 2026-04-30)
Related supplements
Almavivo is for education only, not medical advice. Check with a doctor or pharmacist before starting a supplement, especially if you take prescription medicine, are pregnant or breastfeeding, or have a long-term health condition.